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ea0035p834 | Pituitary Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Expression of peroxisome-proliferator activated receptor α in pituitary tumours

Rotondi Sandra , Modarelli Alessio , Rostomyan Lilya , Oliva Maria Antonietta , Esposito Vincenzo , Ventura Luca , Arcella Antonietta , Alesse Edoardo , Beckers Albert , Jaffrain-Rea Marielise

Peroxisome-proliferator activated receptors (PPARs) are involved in a number of neoplasia. PPARα (PPARα) is a partner of the aryl hydrocarbon receptor interacting protein (AIP), which is involved in the pathogenesis of pituitary adenomas (PA). We wished to investigate the potential expression and biological significance of PPARα in PA, especially in GH/PRL-secreting tumours.Material and methods: A large series of PA was collected (n</e...

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ea0073pep13.1 | Presented ePosters 13: Pituitary and Neuroendocrinology | ECE2021

Factors associated with Aryl hydrocarbon Interacting Protein (AIP) expression in gonadotroph pituitary neuroendocrine tumours (Pit-NETs)

Polidoro Michela A. , Feola Tiziana , Gianno Francesca , Palumbo Valeria , Arcella Antonietta , Morace Roberta , De Angelis Michelangelo , Giangaspero Felice , Esposito Vincenzo , Jaffrain-Rea Marie-Lise

IntroductionAIP is a predisposing gene for GH/PRL-secreting PitNETs. Clinically non-functioning PitNETs (NFPT) occasionally occur in the setting of AIP germline mutations, sometimes arising from Pit-1 lineages. However, AIP overexpression has been observed in unselected NFPT and associations with the gonadotroph phenotype and/or tumour aggressiveness were suggested. We wished to evaluate the significance of AIP expression in gonadotroph tumours defined b...

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Endocrine Abstracts

Expression of peroxisome-proliferator activated receptor α in pituitary tumours

Factors associated with Aryl hydrocarbon Interacting Protein (AIP) expression in gonadotroph pituitary neuroendocrine tumours (Pit-NETs)

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